Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR

Cystic fibrosis (CF) is caused by dysfunction of the epithelial anion channel cystic fibrosis transmembrane conductance regulator (CFTR). One strategy to restore function to CF mutants is to suppress defects in CFTR processing and function using revertant mutations. Here, we investigate the effects...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Xu, Zhe, Pissarra, Luísa S, Farinha, Carlos M, Liu, Jia, Cai, Zhiwei, Thibodeau, Patrick H, Amaral, Margarida D, Sheppard, David N
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Molecular and Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230770/
https://ncbi.nlm.nih.gov/pubmed/24591578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.271817
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados