Genetic Analysis of a Novel Tubulin Mutation That Redirects Synaptic Vesicle Targeting and Causes Neurite Degeneration in C. elegans

Neuronal cargos are differentially targeted to either axons or dendrites, and this polarized cargo targeting critically depends on the interaction between microtubules and molecular motors. From a forward mutagenesis screen, we identified a gain-of-function mutation in the C. elegans α-tubulin gene...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hsu, Jiun-Min, Chen, Chun-Hao, Chen, Yen-Chih, McDonald, Kent L., Gurling, Mark, Lee, Albert, Garriga, Gian, Pan, Chun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230729/
https://ncbi.nlm.nih.gov/pubmed/25392990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004715
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