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SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1
BACKGROUND: Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic cleavages and the activation of the receptor. A...
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| Veröffentlicht in: | Cell Regen |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4230724/ https://ncbi.nlm.nih.gov/pubmed/25408867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-9769-1-4 |
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