SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1

BACKGROUND: Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic cleavages and the activation of the receptor. A...

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Bibliografiske detaljer
Udgivet i:Cell Regen
Main Authors: Yin, Wenguang, Liu, Dapeng, Liu, Nian, Xu, Liangliang, Li, Song, Lin, Shuo, Shu, Xiaodong, Pei, Duanqing
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230724/
https://ncbi.nlm.nih.gov/pubmed/25408867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-9769-1-4
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