Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer

BACKGROUND: Family history of prostate cancer is a well-recognized risk factor. Previous linkage studies have reported a putative prostate cancer susceptibility locus at chromosome 17q21-22. SPOP (Speckle-type POZ protein)maps to the 17q21-22 candidate linkage region and is one of the most frequentl...

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Detalhes bibliográficos
Publicado no:Prostate
Main Authors: Zuhlke, Kimberly A., Johnson, Anna M., Tomlins, Scott A., Palanisamy, Nallasivam, Carpten, John D., Lange, Ethan M., Isaacs, William B., Cooney, Kathleen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230298/
https://ncbi.nlm.nih.gov/pubmed/24796539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22818
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