MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway

Hyperglycemia is one of the possible causes for osteoporosis and bone fracture in diabetes mellitus. Here we modeled diabetes-induced osteoporosis in vitro using preosteoblastic cell line MC3T3-E1 and a diabetic mice model for in vivo studies. We found that in addition to reducing osteoblast viabili...

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Dades bibliogràfiques
Publicat a:Int J Clin Exp Pathol
Autors principals: You, Li, Gu, Wensha, Chen, Lin, Pan, Ling, Chen, Jinyu, Peng, Yongde
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230144/
https://ncbi.nlm.nih.gov/pubmed/25400823
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