Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8

Methyltransferase-like protein 3 (METTL3) regulates multiple cell functions and diseases by modulating N(6)-methyladenosine (m(6)A) modifications. However, it is still unclear whether METTL3 involves in the pathogenesis of diabetic retinopathy (DR). In the present study, we found that high-glucose i...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Zha, Xu, Xi, Xiaoting, Fan, Xinyu, Ma, Minjun, Zhang, Yuanping, Yang, Yanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244028/
https://ncbi.nlm.nih.gov/pubmed/32365051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103130
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