Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pastan, I H, Archer, G E, McLendon, R E, Friedman, H S, Fuchs, H E, Wang, Q C, Pai, L H, Herndon, J, Bigner, D D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7708720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.7.2765
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