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Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination

[Image: see text] We recently demonstrated that variants of cytochrome P450(BM3) (CYP102A1) catalyze the insertion of nitrogen species into benzylic C–H bonds to form new C–N bonds. An outstanding challenge in the field of C–H amination is catalyst-controlled regioselectivity. Here, we report two en...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Hyster, Todd K., Farwell, Christopher C., Buller, Andrew R., McIntosh, John A., Arnold, Frances H.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227740/
https://ncbi.nlm.nih.gov/pubmed/25325618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja509308v
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