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Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
[Image: see text] One of the greatest challenges in protein design is creating new enzymes, something evolution does all the time, starting from existing ones. Borrowing from nature’s evolutionary strategy, we have engineered a bacterial cytochrome P450 to catalyze highly enantioselective intermolec...
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| Published in: | ACS Cent Sci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical Society
2015
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571169/ https://ncbi.nlm.nih.gov/pubmed/26405689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00056 |
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