Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN

[Image: see text] RlmN and Cfr are methyltransferases/methylsynthases that belong to the radical S-adenosylmethionine superfamily of enzymes. RlmN catalyzes C2 methylation of adenosine 2503 (A2503) of 23S rRNA, while Cfr catalyzes C8 methylation of the exact same nucleotide, and will subsequently ca...

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Udgivet i:J Am Chem Soc
Main Authors: Silakov, Alexey, Grove, Tyler L., Radle, Matthew I., Bauerle, Matthew R., Green, Michael T., Rosenzweig, Amy C., Boal, Amie K., Booker, Squire J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227720/
https://ncbi.nlm.nih.gov/pubmed/24806349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja410560p
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