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One-Electron Oxidation of Gemcitabine and Analogs: Mechanism of Formation of C3′ and C2′ Sugar Radicals
[Image: see text] Gemcitabine is a modified cytidine analog having two fluorine atoms at the 2′-position of the ribose ring. It has been proposed that gemcitabine inhibits RNR activity by producing a C3′• intermediate via direct H3′-atom abstraction followed by loss of HF to yield a C2′• with 3′-ket...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4227712/ https://ncbi.nlm.nih.gov/pubmed/25296262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5083156 |
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