One-Electron Oxidation of Gemcitabine and Analogs: Mechanism of Formation of C3′ and C2′ Sugar Radicals

[Image: see text] Gemcitabine is a modified cytidine analog having two fluorine atoms at the 2′-position of the ribose ring. It has been proposed that gemcitabine inhibits RNR activity by producing a C3′• intermediate via direct H3′-atom abstraction followed by loss of HF to yield a C2′• with 3′-ket...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Adhikary, Amitava, Kumar, Anil, Rayala, Ramanjaneyulu, Hindi, Ragda M., Adhikary, Ananya, Wnuk, Stanislaw F., Sevilla, Michael D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227712/
https://ncbi.nlm.nih.gov/pubmed/25296262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5083156
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