Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

BACKGROUND: Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. METHODS: α-Mangostin (AM) was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-d...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Ibrahim, Mohamed Yousif, Hashim, Najihah Mohd, Mohan, Syam, Abdulla, Mahmood Ameen, Abdelwahab, Siddig Ibrahim, Kamalidehghan, Behnam, Ghaderian, Mostafa, Dehghan, Firouzeh, Ali, Landa Zeenelabdin, Karimian, Hamed, Yahayu, Maizatulakmal, Ee, Gwendoline Cheng Lian, Farjam, Abdoreza Soleimani, Ali, Hapipah Mohd
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2014
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227646/
https://ncbi.nlm.nih.gov/pubmed/25395836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S66574
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