Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

BACKGROUND: Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. METHODS: α-Mangostin (AM) was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-d...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Drug Des Devel Ther
المؤلفون الرئيسيون: Ibrahim, Mohamed Yousif, Hashim, Najihah Mohd, Mohan, Syam, Abdulla, Mahmood Ameen, Abdelwahab, Siddig Ibrahim, Kamalidehghan, Behnam, Ghaderian, Mostafa, Dehghan, Firouzeh, Ali, Landa Zeenelabdin, Karimian, Hamed, Yahayu, Maizatulakmal, Ee, Gwendoline Cheng Lian, Farjam, Abdoreza Soleimani, Ali, Hapipah Mohd
التنسيق: Artigo
اللغة:Inglês
منشور في: Dove Medical Press 2014
الموضوعات:
Original Research
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227646/
https://ncbi.nlm.nih.gov/pubmed/25395836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S66574
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