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In vivo regulation of TGFβ by R-Ras2 revealed through loss of the RasGAP protein NF1

Ras superfamily proteins participate in TGFβ-mediated developmental pathways that promote either tumor suppression or progression. However, the specific Ras proteins which integrate in vivo with TGFβ signaling pathways are unknown. As a general approach to this question, we activated all Ras protein...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Patmore, Deanna M, Welch, Sara, Fulkerson, Patricia C, Wu, Jianqiang, Choi, Kwangmin, Eaves, David, Kordich, Jennifer J, Collins, Margaret H, Cripe, Timothy P, Ratner, Nancy
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227504/
https://ncbi.nlm.nih.gov/pubmed/22918885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1972
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