A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death

The Ras GTPase-activating protein RasGAP catalyzes the conversion of active GTP-bound Ras into inactive GDP-bound Ras. However, RasGAP also acts as a positive effector of Ras and exerts an anti-apoptotic activity that is independent of its GAP function and that involves its SH3 (Src homology) domain...

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Auteurs principaux: Pamonsinlapatham, Perayot, Hadj-Slimane, Réda, Raynaud, Françoise, Bickle, Marc, Corneloup, Claudine, Barthelaix, Audrey, Lepelletier, Yves, Mercier, Perrine, Schapira, Matthieu, Samson, Jérôme, Mathieu, Anne-Laure, Hugo, Nicolas, Moncorgé, Olivier, Mikaelian, Ivan, Dufour, Sylvie, Garbay, Christiane, Colas, Pierre
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483412/
https://ncbi.nlm.nih.gov/pubmed/18682833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002902
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