A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

BACKGROUND: The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and episodes of clinical malaria. METHODS: Using data from 5,144 participants in nine p...

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Publicado en:BMC Med
Main Authors: White, Michael T, Bejon, Philip, Olotu, Ally, Griffin, Jamie T, Bojang, Kalifa, Lusingu, John, Salim, Nahya, Abdulla, Salim, Otsyula, Nekoye, Agnandji, Selidji T, Lell, Bertrand, Asante, Kwaku Poku, Owusu-Agyei, Seth, Mahama, Emmanuel, Agbenyega, Tsiri, Ansong, Daniel, Sacarlal, Jahit, Aponte, John J, Ghani, Azra C
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227280/
https://ncbi.nlm.nih.gov/pubmed/25012228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-014-0117-2
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