Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

Liver X receptors (LXRs) have been proposed to have some anticancer properties, through molecular mechanisms that remain elusive. Here we report for the first time that LXR ligands induce caspase-1-dependent cell death of colon cancer cells. Caspase-1 activation requires Nod-like-receptor pyrin doma...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Derangère, V, Chevriaux, A, Courtaut, F, Bruchard, M, Berger, H, Chalmin, F, Causse, S Z, Limagne, E, Végran, F, Ladoire, S, Simon, B, Boireau, W, Hichami, A, Apetoh, L, Mignot, G, Ghiringhelli, F, Rébé, C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227150/
https://ncbi.nlm.nih.gov/pubmed/25124554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.117
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