GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein

Mutation or multiplication of the alpha-synuclein (Syn)-encoding gene is frequent cause of early onset Parkinson's disease (PD). Recent evidences point to the pathogenic role of excess Syn also in sporadic PD. Syn is a cytosolic protein, which has been shown to be released from neurons. Here we...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Bellani, S, Mescola, A, Ronzitti, G, Tsushima, H, Tilve, S, Canale, C, Valtorta, F, Chieregatti, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227148/
https://ncbi.nlm.nih.gov/pubmed/25124556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.111
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