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Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein

Impaired adult neurogenesis and axon traumatic injury participate in the severity of neurodegenerative diseases. Alpha-synuclein, a cytosolic protein involved in Parkinson’s disease, may be released from neurons, suggesting a role for excess secreted alpha-synuclein in the onset and spread of the pa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tilve, Sharada, Difato, Francesco, Chieregatti, Evelina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642265/
https://ncbi.nlm.nih.gov/pubmed/26558842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16524
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