Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Stress granules (SGs) are mRNA-protein aggregates induced during stress, which accumulate in many neurodegenerative diseases. Previously, the autophagy-lysosome pathway and valosin-containing protein (VCP), key players of the protein quality control (PQC), were shown to regulate SG degradation. This...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Seguin, S J, Morelli, F F, Vinet, J, Amore, D, De Biasi, S, Poletti, A, Rubinsztein, D C, Carra, S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227144/
https://ncbi.nlm.nih.gov/pubmed/25034784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.103
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