Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities

Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standard of care therapeutic in the treatment of colorectal cancer in combination with 5-fluorouracil. One of the major clinical issues limiting the use of i...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Invest New Drugs
Autori principali: Waterhouse, Dawn N., Sutherland, Brent W., Santos, Nancy Dos, Masin, Dana, Osooly, Maryam, Strutt, Dita, Ostlund, Christina, Anantha, Malathi, Harasym, Natashia, Manisali, Irina, Wehbe, Mohamed, Bally, Marcel B., Webb, Murray S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2014
Soggetti:
Preclinical Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226839/
https://ncbi.nlm.nih.gov/pubmed/25064374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0138-x
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