Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities

Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standard of care therapeutic in the treatment of colorectal cancer in combination with 5-fluorouracil. One of the major clinical issues limiting the use of i...

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Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Waterhouse, Dawn N., Sutherland, Brent W., Santos, Nancy Dos, Masin, Dana, Osooly, Maryam, Strutt, Dita, Ostlund, Christina, Anantha, Malathi, Harasym, Natashia, Manisali, Irina, Wehbe, Mohamed, Bally, Marcel B., Webb, Murray S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Preclinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226839/
https://ncbi.nlm.nih.gov/pubmed/25064374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0138-x
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