Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice

A present challenge in breast oncology research is to identify therapeutical targets which could impact tumor progression. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 20% of breast cancers, and NTSR1 overexpression was shown to predict a poor prognosis for 5 year ove...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Dupouy, Sandra, Doan, Van Kien, Wu, Zherui, Mourra, Najat, Liu, Jin, De Wever, Olivier, Llorca, Frédérique Penault, Cayre, Anne, Kouchkar, Amal, Gompel, Anne, Forgez, Patricia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226680/
https://ncbi.nlm.nih.gov/pubmed/25249538
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