aHIF but not HIF-1α transcript is a poor prognostic marker in human breast cancer

BACKGROUND: Hypoxia-inducible factor-1α (HIF-1α) is part of a transcriptional factor that regulates genes involved in metabolic and vascular adaptation of tumours to oxygen restriction. A splicing variant lacking exon 14 (sHIF-1α) encodes a truncated protein that competes with the normal HIF-1α prot...

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Bibliografiske detaljer
Main Authors: Cayre, Anne, Rossignol, Fabrice, Clottes, Eric, Penault-Llorca, Frédérique
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC314412/
https://ncbi.nlm.nih.gov/pubmed/14580258
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