Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

Alterations in the signaling pathways of epidermal growth factor receptors (HERs) are associated with tumor aggressiveness. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 60% of lung cancers. In a previous clinical study, NTSR1 overexpression was shown to predict a poor...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Younes, Mohamad, Wu, Zherui, Dupouy, Sandra, Lupo, Audrey Mansuet, Mourra, Najat, Takahashi, Takashi, Fléjou, Jean François, Trédaniel, Jean, Régnard, Jean François, Damotte, Diane, Alifano, Marco, Forgez, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226681/
https://ncbi.nlm.nih.gov/pubmed/25249545
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