Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

Alterations in the signaling pathways of epidermal growth factor receptors (HERs) are associated with tumor aggressiveness. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 60% of lung cancers. In a previous clinical study, NTSR1 overexpression was shown to predict a poor...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Younes, Mohamad, Wu, Zherui, Dupouy, Sandra, Lupo, Audrey Mansuet, Mourra, Najat, Takahashi, Takashi, Fléjou, Jean François, Trédaniel, Jean, Régnard, Jean François, Damotte, Diane, Alifano, Marco, Forgez, Patricia
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226681/
https://ncbi.nlm.nih.gov/pubmed/25249545
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