Human CD4(+)CD39(+) regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73(+) exosomes or CD73(+) cells

While murine CD4(+)CD39(+) regulatory T cells (T(reg)) co-express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive adenosine (ADO), surface co-expression of CD73 on human circulating CD4(+)CD39(+) T(reg) is rare. Therefore, the ability of human T(reg) to produce and...

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Bibliographic Details
Published in:Clin Exp Immunol
Main Authors: Schuler, P J, Saze, Z, Hong, C-S, Muller, L, Gillespie, D G, Cheng, D, Harasymczuk, M, Mandapathil, M, Lang, S, Jackson, E K, Whiteside, T L
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226604/
https://ncbi.nlm.nih.gov/pubmed/24749746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12354
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