Interface dynamics explain assembly dependency of influenza neuraminidase catalytic activity

Influenza virus neuraminidase (iNA) is a homotetrameric surface protein of the influenza virus and an established target for antiviral drugs. In contrast to neuraminidases (NAs) of other biological systems (non-iNAs), enzymatic activity of iNA is only observed in a quaternary assembly and iNA needs...

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Pubblicato in:J Biomol Struct Dyn
Autori principali: von Grafenstein, Susanne, Wallnoefer, Hannes G., Kirchmair, Johannes, Fuchs, Julian E., Huber, Roland G., Schmidtke, Michaela, Sauerbrei, Andreas, Rollinger, Judith M., Liedl, Klaus R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226318/
https://ncbi.nlm.nih.gov/pubmed/24279589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2013.855142
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