Tyrosine Phosphorylation of the Guanine Nucleotide Exchange Factor GIV Promotes Activation of PI3K During Cell Migration

GIV (Gα-interacting vesicle-associated protein; also known as Girdin), enhances Akt activation downstream of multiple growth factor– and G-protein–coupled receptors to trigger cell migration and cancer invasion. Here we demonstrate that GIV is a tyrosine phosphoprotein that directly binds to and act...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Lin, Changsheng, Ear, Jason, Pavlova, Yelena, Mittal, Yash, Kufareva, Irina, Ghassemian, Majid, Abagyan, Ruben, Garcia-Marcos, Mikel, Ghosh, Pradipta
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226136/
https://ncbi.nlm.nih.gov/pubmed/21954290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002049
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