Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands

Gram-negative bacteria use N-acyl L-homoserine lactone (AHL) quorum sensing (QS) signals to regulate the expression of myriad phenotypes. Non-native AHL analogs can strongly attenuate QS receptor activity and thereby QS signaling; however, we currently lack a molecular understanding of the mechanism...

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Détails bibliographiques
Publié dans:Chem Biol
Auteurs principaux: Gerdt, Joseph P., McInnis, Christine E., Schell, Trevor L., Rossi, Francis M., Blackwell, Helen E.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224638/
https://ncbi.nlm.nih.gov/pubmed/25242287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.08.008
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