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Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands
Gram-negative bacteria use N-acyl L-homoserine lactone (AHL) quorum sensing (QS) signals to regulate the expression of myriad phenotypes. Non-native AHL analogs can strongly attenuate QS receptor activity and thereby QS signaling; however, we currently lack a molecular understanding of the mechanism...
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| Publicado no: | Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4224638/ https://ncbi.nlm.nih.gov/pubmed/25242287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.08.008 |
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