Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress

Sirtuin3 (SIRT3) is an important member of the sirtuin family of protein deacetylases that is localized to mitochondria and linked to lifespan extension in organisms ranging from yeast to humans. As aged cells have less regenerative capacity and are more susceptible to oxidative stress, we investiga...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Wang, Xue-Qing, Shao, Yong, Ma, Chong-Yi, Chen, Wei, Sun, Lu, Liu, Wei, Zhang, Dong-Yang, Fu, Bi-Cheng, Liu, Kai-Yu, Jia, Zhi-Bo, Xie, Bao-Dong, Jiang, Shu-Lin, Li, Ren-Ke, Tian, Hai
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224562/
https://ncbi.nlm.nih.gov/pubmed/25210848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12395
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