Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress

Sirtuin3 (SIRT3) is an important member of the sirtuin family of protein deacetylases that is localized to mitochondria and linked to lifespan extension in organisms ranging from yeast to humans. As aged cells have less regenerative capacity and are more susceptible to oxidative stress, we investiga...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Wang, Xue-Qing, Shao, Yong, Ma, Chong-Yi, Chen, Wei, Sun, Lu, Liu, Wei, Zhang, Dong-Yang, Fu, Bi-Cheng, Liu, Kai-Yu, Jia, Zhi-Bo, Xie, Bao-Dong, Jiang, Shu-Lin, Li, Ren-Ke, Tian, Hai
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224562/
https://ncbi.nlm.nih.gov/pubmed/25210848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12395
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