Energy Stress Regulates Hippo–YAP Signaling involving AMPK-mediated Regulation of Angiomotin Like-1 Protein

Hippo signaling is a tumor suppressor pathway involved in organ size control and tumorigenesis, through the inhibition of YAP and TAZ. Here we show that energy stress induces YAP cytoplasmic retention and Ser127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformati...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: DeRan, Michael, Yang, Jiayi, Shen, Che-Hung, Peters, Eric C., Fitamant, Julien, Chan, Puiyee, Hsieh, Mindy, Zhu, Shunying, Asara, John M., Zheng, Bin, Bardeesy, Nabeel, Liu, Jun, Wu, Xu
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223634/
https://ncbi.nlm.nih.gov/pubmed/25373897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.036
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