Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors

Aberrant expression of hedgehog molecules, particularly Gli1, is common in cancers of many tissues and is responsible for their aggressive behavior and chemoresistance. Here we demonstrate a novel and tumor-specific role for aberrant Gli1 in the regulation of the S-phase checkpoint that suppresses r...

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Udgivet i:J Biol Chem
Main Authors: Tripathi, Kaushlendra, Mani, Chinnadurai, Barnett, Reagan, Nalluri, Sriram, Bachaboina, Lavanya, Rocconi, Rodney P., Athar, Mohammed, Owen, Laurie B., Palle, Komaraiah
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223349/
https://ncbi.nlm.nih.gov/pubmed/25253693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.606483
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