Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2

Niacin has been demonstrated to activate a PI3K/Akt signaling cascade to prevent brain damage after stroke and UV-induced skin damage; however, the underlying molecular mechanisms for HCA(2)-induced Akt activation remain to be elucidated. Using CHO-K1 cells stably expressing HCA(2) and A431 cells, a...

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Pubblicato in:PLoS One
Autori principali: Sun, Huawang, Li, Guo, Zhang, Wenjuan, Zhou, Qi, Yu, Yena, Shi, Ying, Offermanns, Stefan, Lu, Jianxin, Zhou, Naiming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223033/
https://ncbi.nlm.nih.gov/pubmed/25375133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112310
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