Suppression of feedback loops mediated by PI3K/mTOR induces multiple over-activation of compensatory pathways: an unintended consequence leading to drug resistance

Lignende værker

• Dual PI3K/mTOR inhibitors induce rapid over-activation of the MEK/ERK pathway in human pancreatic cancer cells through suppression of mTORC2
  af: Soares, Heloisa P., et al.
  Udgivet: (2015)
• Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells
  af: Soares, Heloisa P., et al.
  Udgivet: (2013)
• Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy.
  af: Anuja Sathe, et al.
  Udgivet: (2018-01-01)
• Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy
  af: Sathe, Anuja, et al.
  Udgivet: (2018)
• Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas
  af: Bhatt, Aadra P., et al.
  Udgivet: (2010)