Predictive Gene Signature of Response to the Anti-TweakR mAb PDL192 in Patient-Derived Breast Cancer Xenografts

PURPOSE: (1) To determine TweakR expression in human breast cancers (BC), (2) evaluate the antitumor effect of the anti-TweakR antibody PDL192, used alone or after chemotherapy-induced complete remission (CR), on patient-derived BC xenografts (PDX) and (3) define predictive markers of response. EXPE...

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Bibliographic Details
Published in:PLoS One
Main Authors: de Plater, Ludmilla, Vincent-Salomon, Anne, Berger, Frédérique, Nicolas, André, Vacher, Sophie, Gravier, Eléonore, Thuleau, Aurélie, Karboul, Narjesse, Richardson, Marion, Elbaz, Clément, Marangoni, Elisabetta, Bièche, Ivan, Paoletti, Xavier, Roman-Roman, Sergio, Culp, Patricia A., Asselain, Bernard, Diéras, Véronique, Decaudin, Didier
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222831/
https://ncbi.nlm.nih.gov/pubmed/25375638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104227
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