Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides

Aptamer ligands for myelin basic protein (MBP) were obtained using the systematic evolution of ligand by exponential enrichment (SELEX) method. Two clones were isolated from a pool of oligonucleotides and tested for MBP targeting. Using purified MBP, we demonstrated the binding activity of the aptam...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Rozenblum, Guido Tomás, Kaufman, Tomás, Vitullo, Alfredo Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222649/
https://ncbi.nlm.nih.gov/pubmed/25202925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.43
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