Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

BACKGROUND: LEDGF/p75 (LEDGF) is the main cellular cofactor of HIV-1 integrase (IN). It acts as a tethering factor for IN, and targets the integration of HIV in actively transcribed gene regions of chromatin. A recently developed class of IN allosteric inhibitors can inhibit the LEDGF-IN interaction...

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Publicat a:Retrovirology
Autors principals: Le Rouzic, Erwann, Bonnard, Damien, Chasset, Sophie, Bruneau, Jean-Michel, Chevreuil, Francis, Le Strat, Frédéric, Nguyen, Juliette, Beauvoir, Roxane, Amadori, Céline, Brias, Julie, Vomscheid, Sophie, Eiler, Sylvia, Lévy, Nicolas, Delelis, Olivier, Deprez, Eric, Saïb, Ali, Zamborlini, Alessia, Emiliani, Stéphane, Ruff, Marc, Ledoussal, Benoit, Moreau, François, Benarous, Richard
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222603/
https://ncbi.nlm.nih.gov/pubmed/24261564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-144
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