Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

BACKGROUND: Everolimus (EVE) is a drug widely used in several renal transplant protocols. Although characterized by a relatively low nephrotoxicity, it may induce several adverse effects including severe fibro-interstitial pneumonitis. The exact molecular/biological mechanism associated to these pro...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Masola, Valentina, Zaza, Gianluigi, Granata, Simona, Gambaro, Giovanni, Onisto, Maurizio, Lupo, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222256/
https://ncbi.nlm.nih.gov/pubmed/24256696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-292
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