A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition

BACKGROUND: Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling of FGF-2, a growth factor involved in this mechanism, is regulated by glycosaminoglycans. Heparanase-1, an endoglycosidase t...

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Main Authors: Masola, Valentina, Onisto, Maurizio, Zaza, Gianluigi, Lupo, Antonio, Gambaro, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562257/
https://ncbi.nlm.nih.gov/pubmed/23095131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-213
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