Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical application

BACKGROUND: TP53 defects, i.e. 17p13 deletion and/or nucleotide mutations, associate with short survival and chemorefractoriness in chronic lymphocytic leukemia (CLL). In this context, since direct sequencing of the TP53 gene does not evaluate TP53 functionality, a functional assessment of TP53 path...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Hematol Oncol
المؤلفون الرئيسيون: Pozzo, Federico, Dal Bo, Michele, Peragine, Nadia, Bomben, Riccardo, Zucchetto, Antonella, Rossi, Francesca Maria, Degan, Massimo, Rossi, Davide, Chiarenza, Annalisa, Grossi, Alberto, Di Raimondo, Francesco, Zaja, Francesco, Pozzato, Gabriele, Secchiero, Paola, Gaidano, Gianluca, Del Poeta, Giovanni, Zauli, Giorgio, Foà, Robin, Guarini, Anna, Gattei, Valter
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2013
الموضوعات:
Research
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222122/
https://ncbi.nlm.nih.gov/pubmed/24283248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-83
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة