Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical application

BACKGROUND: TP53 defects, i.e. 17p13 deletion and/or nucleotide mutations, associate with short survival and chemorefractoriness in chronic lymphocytic leukemia (CLL). In this context, since direct sequencing of the TP53 gene does not evaluate TP53 functionality, a functional assessment of TP53 path...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Pozzo, Federico, Dal Bo, Michele, Peragine, Nadia, Bomben, Riccardo, Zucchetto, Antonella, Rossi, Francesca Maria, Degan, Massimo, Rossi, Davide, Chiarenza, Annalisa, Grossi, Alberto, Di Raimondo, Francesco, Zaja, Francesco, Pozzato, Gabriele, Secchiero, Paola, Gaidano, Gianluca, Del Poeta, Giovanni, Zauli, Giorgio, Foà, Robin, Guarini, Anna, Gattei, Valter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222122/
https://ncbi.nlm.nih.gov/pubmed/24283248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-83
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