The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer

BACKGROUND: While colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain undefined. GUCY2C has emerged as an intestine-specific tumor suppressor controlling epitheli...

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Bibliographic Details
Published in:Cancer Epidemiol Biomarkers Prev
Main Authors: Wilson, Chantell, Lin, Jieru E., Li, Peng, Snook, Adam E., Gong, Jianping, Sato, Takahiro, Liu, Chengbao, Girondo, Melanie A., Rui, Hallgeir, Hyslop, Terry, Waldman, Scott A.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221461/
https://ncbi.nlm.nih.gov/pubmed/25304930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-14-0440
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