Primary Ovarian Carcinomas and Abdominal Metastasis Contain 4,6-Disulfated Chondroitin Sulfate Rich Regions, Which Provide Adhesive Properties to Tumour Cells

High mortality in ovarian cancer patients is primarily caused through rapid metastasis of the tumour, but the underlying mechanisms are poorly understood. Glycosaminoglycans, are abundantly present in tumours and chondroitin sulfate-E (CSE), a highly 4,6-sulfated glycosaminoglycan, has been indicate...

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Bibliographic Details
Published in:PLoS One
Main Authors: Vallen, Myrtille J. E., Schmidt, Samuel, Oosterhof, Arie, Bulten, Johan, Massuger, Leon F. A. G., van Kuppevelt, Toin H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221137/
https://ncbi.nlm.nih.gov/pubmed/25372710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111806
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