Primary Ovarian Carcinomas and Abdominal Metastasis Contain 4,6-Disulfated Chondroitin Sulfate Rich Regions, Which Provide Adhesive Properties to Tumour Cells

High mortality in ovarian cancer patients is primarily caused through rapid metastasis of the tumour, but the underlying mechanisms are poorly understood. Glycosaminoglycans, are abundantly present in tumours and chondroitin sulfate-E (CSE), a highly 4,6-sulfated glycosaminoglycan, has been indicate...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Vallen, Myrtille J. E., Schmidt, Samuel, Oosterhof, Arie, Bulten, Johan, Massuger, Leon F. A. G., van Kuppevelt, Toin H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221137/
https://ncbi.nlm.nih.gov/pubmed/25372710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111806
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