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Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias
Human ryanodine receptor 2 (hRyR2) mediates calcium release from the sarcoplasmic reticulum, enabling cardiomyocyte contraction. The N-terminal region of hRyR2 (amino acids 1–606) is the target of >30 arrhythmogenic mutations and contains a binding site for phosphoprotein phosphatase 1. Here, th...
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| Gepubliceerd in: | Acta Crystallogr D Biol Crystallogr |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
International Union of Crystallography
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4220973/ https://ncbi.nlm.nih.gov/pubmed/25372681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714020343 |
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