Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias

Human ryanodine receptor 2 (hRyR2) mediates calcium release from the sarcoplasmic reticulum, enabling cardio­myocyte contraction. The N-terminal region of hRyR2 (amino acids 1–606) is the target of >30 arrhythmogenic mutations and contains a binding site for phosphoprotein phosphatase 1. Here, th...

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Detalles Bibliográficos
Publicado en:Acta Crystallogr D Biol Crystallogr
Main Authors: Borko, Ľubomír, Bauerová-Hlinková, Vladena, Hostinová, Eva, Gašperík, Juraj, Beck, Konrad, Lai, F. Anthony, Zahradníková, Alexandra, Ševčík, Jozef
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2014
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220973/
https://ncbi.nlm.nih.gov/pubmed/25372681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714020343
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