LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling

The receptor tyrosine kinase Flt3 and its ligand are crucial for dendritic cell (DC) homeostasis by activating downstream effectors including mammalian target of Rapamycin (mTOR) signalling. LAMTOR2 is a member of the Ragulator/LAMTOR complex known to regulate mTOR and extracellular signal-regulated...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Scheffler, Julia M., Sparber, Florian, Tripp, Christoph H., Herrmann, Caroline, Humenberger, Alexandra, Blitz, Johanna, Romani, Nikolaus, Stoitzner, Patrizia, Huber, Lukas A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220488/
https://ncbi.nlm.nih.gov/pubmed/25336251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6138
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