LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling

The receptor tyrosine kinase Flt3 and its ligand are crucial for dendritic cell (DC) homeostasis by activating downstream effectors including mammalian target of Rapamycin (mTOR) signalling. LAMTOR2 is a member of the Ragulator/LAMTOR complex known to regulate mTOR and extracellular signal-regulated...

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Vydáno v:Nat Commun
Hlavní autoři: Scheffler, Julia M., Sparber, Florian, Tripp, Christoph H., Herrmann, Caroline, Humenberger, Alexandra, Blitz, Johanna, Romani, Nikolaus, Stoitzner, Patrizia, Huber, Lukas A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220488/
https://ncbi.nlm.nih.gov/pubmed/25336251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6138
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