Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis

Taspase1, a highly conserved threonine protease, cleaves nuclear transcriptional regulators mixed-lineage leukemia (MLL, MLL1), MLL2, TFIIA, and ALF to orchestrate a wide variety of biological processes. In vitro studies thus far demonstrated that Taspase1 plays important roles in the proliferation...

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Bibliografske podrobnosti
izdano v:Cell Res
Main Authors: Dong, Yiyu, Van Tine, Brian A, Oyama, Toshinao, Wang, Patricia I, Cheng, Emily H, Hsieh, James J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220155/
https://ncbi.nlm.nih.gov/pubmed/25267403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.129
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